Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers.

Oncotarget - 10 Mar 2015

Xiang Libing, Li Jiajia, Jiang Wei, Shen Xuxia, Yang Wentao, Wu Xiaohua, Yang Huijuan

Abstract excerpt

Mutations in 16 targetable oncogenic genes were examined using reverse transcription polymerase chain reaction (RT-PCR) and direct sequencing in 285 Chinese cervical cancers. Their clinicopathological relevance and prognostic significance was assessed. Ninety-two nonsynonymous somatic mutations were identified in 29.8% of the cancers. The mutation rates were as follows: PIK3CA (12.3%), KRAS (5.3%), HER2 (4.2%),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to Mutation

Share to Phosphatidylinositol 3-Kinases

Share to ras Proteins

Share to Treatment Outcome

Share to Uterine Cervical Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25669975
DOI: 10.18632/oncotarget.3212
PMCID: PMC4467127

Genes

FGFR3
PTEN
RET
AKT1
ALK
BRAF
CCDC6
EGFR
EML4
FGFR1
FGFR2
HRAS
KRAS
NRAS
TACC1
TACC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers.PMID 25669975Read ↗

Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusionsSemantic proximity Read ↗

Exploiting somatic alterations as therapeutic targets in advanced and metastatic cervical cancer.Semantic proximity Read ↗

Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.Semantic proximity Read ↗

Genomic analysis of cervical carcinoma identifies Alpelisib as a therapeutic option for PIK3CA-mutant cervical carcinoma via the PI3K/AKT pathway.Semantic proximity Read ↗

High incidence of PI3K pathway gene mutations in South Indian cervical cancers.Semantic proximity Read ↗

PIK3CA mutation analysis in Chinese patients with surgically resected cervical cancer.Semantic proximity Read ↗

Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix.Semantic proximity Read ↗

Clinical implication of oncogenic somatic mutations in early-stage cervical cancer with radical hysterectomy.Semantic proximity Read ↗

Tongue carcinoma infrequently harbor common actionable genetic alterations.Semantic proximity Read ↗

Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like breast cancers from Caucasian women.Semantic proximity Read ↗

Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapySemantic proximity Read ↗

Prevalence and Prognostic Significance of PIK3CA Mutation and CNV Status and Phosphorylated AKT Expression in Patients With Cervical Cancer Treated With Primary Surgery.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.