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Article

Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.

Scientific reports - 11 Feb 2015

Nguyen Thi Thuy Trang, Lim Julia Sze Lynn, Tang Richard Ming Yi, Zhang Louxin, Chen Ee Sin

Abstract excerpt

Doxorubicin, a chemotherapeutic agent, inhibits the religation step of topoisomerase II (Top2). However, the downstream ramifications of this action are unknown. Here we performed epistasis analyses of top2 with 63 genes representing doxorubicin resistance (DXR) genes in fission yeast and revealed a subset that synergistically collaborate with Top2 to confer DXR. Our findings show that the chromatin-regulating...

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Identifiers

PMID: 25669599
DOI: 10.1038/srep08400
PMCID: PMC4323662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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