Article
Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy.
Disease models & mechanisms - 1 Apr 2021
Oprişoreanu Ana-Maria, Smith Hannah L, Krix Sophia, Chaytow Helena, Carragher Neil O, Gillingwater Thomas H, Becker Catherina G, Becker Thomas
Abstract excerpt
Synapses are particularly vulnerable in many neurodegenerative diseases and often the first to degenerate, for example in the motor neuron disease spinal muscular atrophy (SMA). Compounds that can counteract synaptic destabilisation are rare. Here, we describe an automated screening paradigm in zebrafish for small-molecule compounds that stabilize the neuromuscular synapse in vivo. We make use of a mutant for the...
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