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Article

14-3-3σ regulates keratinocyte proliferation and differentiation by modulating Yap1 cellular localization.

The Journal of investigative dermatology - 1 Jun 2015

Sambandam Sumitha A T, Kasetti Ramesh B, Xue Lei, Dean Douglas C, Lu Qingxian, Li Qiutang

Abstract excerpt

The homozygous repeated epilation (Er/Er) mouse mutant of the gene encoding 14-3-3σ displays an epidermal phenotype characterized by hyperproliferative keratinocytes and undifferentiated epidermis. Heterozygous Er/+ mice develop spontaneous skin tumors and are highly sensitive to tumor-promoting 7,12-dimethylbenzanthracene/12-O-tetradecanoyl-phorbol-13-acetate induction. The molecular mechanisms underlying...

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Source

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Identifiers

PMID: 25668240
DOI: 10.1038/jid.2015.42
PMCID: PMC4430425

Genes

YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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