Article
DNA methylation-independent growth restriction and altered developmental programming in a mouse model of preconception male alcohol exposure.
Epigenetics - 1 Jan 2017
Chang Richard C, Skiles William M, Chronister Sarah S, Wang Haiqing, Sutton Gabrielle I, Bedi Yudhishtar S, Snyder Matthew, Long Charles R, Golding Michael C
Abstract excerpt
The preconception environment is a significant modifier of dysgenesis and the development of environmentally-induced disease. To date, fetal alcohol spectrum disorders (FASDs) have been exclusively associated with maternal exposures, yet emerging evidence suggests male-inherited alterations in the developmental program of sperm may be relevant to the growth-restriction phenotypes of this condition. Using a mouse...
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