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Article

Ageing and interferon gamma response drive the phenotype of neutrophils in the inflamed joint.

Annals of the rheumatic diseases - 1 Jun 2022

Grieshaber-Bouyer Ricardo, Exner Tarik, Hackert Nicolaj S, Radtke Felix A, Jelinsky Scott A, Halyabar Olha, Wactor Alexandra, Karimizadeh Elham, Brennan Joseph, Schettini Jorge, Jonsson Helena, Rao Deepak A, Henderson Lauren A, Müller-Tidow Carsten, Lorenz Hanns-Martin, Wabnitz Guido, Lederer James A, Hadjipanayis Angela, Nigrovic Peter A

Abstract excerpt

OBJECTIVE: Neutrophils are typically the most abundant leucocyte in arthritic synovial fluid. We sought to understand changes that occur in neutrophils as they migrate from blood to joint. METHODS: We performed RNA sequencing of neutrophils from healthy human blood, arthritic blood and arthritic synovial fluid, comparing transcriptional signatures with those from murine K/BxN serum transfer arthritis. We employed...

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Identifiers

PMID: 35168946
DOI: 10.1136/annrheumdis-2021-221866
PMCID: PMC9380120

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