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Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

16 Mar 2015

Abstract excerpt

Neutrophil extracellular traps (NETs) are critical for anti-bacterial activity of the innate immune system. We have previously shown that mitochondrial damage-associated molecular patterns (mtDAMPs), including mitochondrial DNA (mtDNA), are released into the circulation after injury. We therefore questioned whether mtDNA is involved in trauma-induced NET formation. Treatment of human polymorphoneutrophils (PMN)...

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PMID: 25774524
DOI: 10.1371/journal.pone.0120549

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