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Article

Soluble Jagged-1 inhibits restenosis of vein graft by attenuating Notch signaling.

Microvascular research - 1 Jul 2015

Zhou Xinming, Xiao Yongguang, Mao Zhifu, Huang Jie, Geng Qing, Wang Wei, Dong Ping

Abstract excerpt

The excessive proliferation of vascular smooth muscle cells was key factor in the restenosis of vein graft. And the Notch signaling was demonstrated to regulate vSMC proliferation and differentiation. Soluble Jagged-1 (sJag1) can inhibit Notch signaling in vitro and in vivo; however, its capacity...

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Share to Carotid Artery, Common
Share to Jagged-1 Protein
Share to Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Smooth Muscle

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Share to Rats, Wistar

Share to Receptor, Notch1

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Source

Identifiers

PMID: 25660475
DOI: 10.1016/j.mvr.2015.01.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25660475-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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