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Article

Soluble JAGGED1 inhibits pulmonary hypertension by attenuating notch signaling.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2013

Xiao Yongguang, Gong Dan, Wang Wei

Abstract excerpt

OBJECTIVE: Notch signaling has been implicated in the development of pulmonary arterial hypertension (PH) as reflected by increased expression of Notch member proteins that induce the proliferation of pulmonary arterial smooth muscle cells (PASMCs). Soluble Jagged1 (sJag1) has been shown to inhibit Notch signaling in vitro and in vivo; however, its capacity to suppress PH remains unknown. APPROACH AND RESULTS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24072692
DOI: 10.1161/ATVBAHA.113.302062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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