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Article

Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese.

Carcinogenesis - 1 Jan 2009

Shiraishi Kouya, Kohno Takashi, Kunitoh Hideo, Watanabe Shun-ichi, Goto Koichi, Nishiwaki Yutaka, Shimada Yoko, Hirose Hiroshi, Saito Ikuo, Kuchiba Aya, Yamamoto Seiichro, Yokota Jun

Abstract excerpt

Recent genome wide association (GWA) studies on European and American populations revealed association with lung cancer risk of single-nucleotide polymorphisms (SNPs) in the locus containing two nicotine acetylcholine receptor (CHRNA) genes, whose involvement in tobacco addiction had been indicated. Association with lung cancer risk in smokers was consistently, but that in non-smokers as well as that with smoking...

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Identifiers

PMID: 19005185
DOI: 10.1093/carcin/bgn257

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