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Article

Genomic Copy Number Analysis of HER2-Equivocal Breast Cancers.

American journal of clinical pathology - 1 Oct 2016

Geiersbach Katherine B, Willmore-Payne Carlynn, Pasi Alexandra V, Paxton Christian N, Werner Theresa L, Xu Xinjie, Wittwer Carl T, Gulbahce H Evin, Downs-Kelly Erinn

Abstract excerpt

OBJECTIVES: Guidelines for HER2 testing define an equivocal range for HER2 using two approved testing methods, immunohistochemistry (IHC) and in situ hybridization (ISH). We investigated genome-wide copy number alterations in this subgroup. METHODS: Ten breast cancers with equivocal HER2 status by both IHC and ISH were analyzed by single-nucleotide polymorphism cytogenomic microarray (SNP array). DNA ploidy...

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Share to Breast Neoplasms
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Comparative Genomic Hybridization

Share to DNA Copy Number Variations

Share to Flow Cytometry

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Source

Identifiers

PMID: 27614666
DOI: 10.1093/ajcp/aqw130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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