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Article

Linking function to global and local dynamics in an elevator-type transporter.

Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2021

Ciftci Didar, Martens Chloe, Ghani Vishnu G, Blanchard Scott C, Politis Argyris, Huysmans Gerard H M, Boudker Olga

Abstract excerpt

Transporters cycle through large structural changes to translocate molecules across biological membranes. The temporal relationships between these changes and function, and the molecular properties setting their rates, determine transport efficiency-yet remain mostly unknown. Using single-molecule fluorescence microscopy, we compare the timing of conformational transitions and substrate uptake in the...

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Identifiers

PMID: 34873050
DOI: 10.1073/pnas.2025520118
PMCID: PMC8670510

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