Article
Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions.
Carcinogenesis - 1 Feb 2007
Manuguerra M, Matullo G, Veglia F, Autrup H, Dunning A M, Garte S, Gormally E, Malaveille C, Guarrera S, Polidoro S, Saletta F, Peluso M, Airoldi L, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Linseisen J, Boeing H, Trichopoulos D, Kalandidi A, Palli D, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita H B, Peeters P H, Lund E, Pera G, Martinez C, Amiano P, Barricarte A, Tormo M J, Quiros J R, Berglund G, Janzon L, Jarvholm B, Day N E, Allen N E, Saracci R, Kaaks R, Ferrari P, Riboli E, Vineis P
Abstract excerpt
It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested...
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