Article
The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans.
PLoS medicine - 1 Feb 2015
Zheng Ming, Zhang Haili, Dill David L, Clark J David, Tu Susan, Yablonovitch Arielle L, Tan Meng How, Zhang Rui, Rujescu Dan, Wu Manhong, Tessarollo Lino, Vieira Wilfred, Gottesman Michael M, Deng Suhua, Eberlin Livia S, Zare Richard N, Billard Jean-Martin, Gillet Jean-Pierre, Li Jin Billy, Peltz Gary
Abstract excerpt
BACKGROUND: We know very little about the genetic factors affecting susceptibility to drug-induced central nervous system (CNS) toxicities, and this has limited our ability to optimally utilize existing drugs or to develop new drugs for CNS disorders. For example, haloperidol is a potent dopamine antagonist that is used to treat psychotic disorders, but 50% of treated patients develop characteristic...
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