Article
A Pharmacogenetic Discovery: Cystamine Protects Against Haloperidol-Induced Toxicity and Ischemic Brain Injury.
Genetics - 1 May 2016
Zhang Haili, Zheng Ming, Wu Manhong, Xu Dan, Nishimura Toshihiko, Nishimura Yuki, Giffard Rona, Xiong Xiaoxing, Xu Li Jun, Clark J David, Sahbaie Peyman, Dill David L, Peltz Gary
Abstract excerpt
Haloperidol is an effective antipsychotic agent, but it causes Parkinsonian-like extrapyramidal symptoms in the majority of treated subjects. To address this treatment-limiting toxicity, we analyzed a murine genetic model of haloperidol-induced toxicity (HIT). Analysis of a panel of consomic strains indicated that a genetic factor on chromosome 10 had a significant effect on susceptibility to HIT. We analyzed a...
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