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Article

p300 arrests intervertebral disc degeneration by regulating the FOXO3 /Sirt1/Wnt/β‐catenin axis

30 Jul 2022

Abstract excerpt

The transcription factor p300 is reportedly involved in age-associated human diseases, including intervertebral disc degeneration (IDD). In this study, we investigate the potential role and pathophysiological mechanism of p300 in IDD. Clinical tissue samples were collected from patients with lumbar disc herniation (LDH), in which the expression of p300, forkhead box O3 (FOXO3), and sirtuin 1 (Sirt1) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35907249
DOI: 10.1111/acel.13677

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