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Article

The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment.

Scientific reports - 1 Jan 2012

Managò Francesca, Espinoza Stefano, Salahpour Ali, Sotnikova Tatyana D, Caron Marc G, Premont Richard T, Gainetdinov Raul R

Abstract excerpt

G protein-coupled Receptor Kinase 6 (GRK6) belongs to a family of kinases that phosphorylate GPCRs. GRK6 levels were found to be altered in Parkinson's Disease (PD) and D(2) dopamine receptors are supersensitive in mice lacking GRK6 (GRK6-KO mice). To understand how GRK6 modulates the behavioral manifestations of dopamine deficiency and responses to L-DOPA, we used three approaches to model PD in GRK6-KO mice: 1)...

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Identifiers

PMID: 22393477
DOI: 10.1038/srep00301
PMCID: PMC3293148

Genes

GRK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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