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Article

Weak association of glyoxalase 1 (GLO1) variants with autism spectrum disorder.

European child & adolescent psychiatry - 1 Jan 2015

Kovač Jernej, Podkrajšek Katarina Trebušak, Lukšič Marta Macedoni, Battelino Tadej

Abstract excerpt

The prevalence of the autism spectrum disorder (ASD) was recently estimated to 1 in 88 children by the CDC MMWR. In up to 25 % of the cases, the genetic cause can be identified. Past studies identified increased level of advanced glycation end products (AGE) in the brain samples of ASD patients. The methylglyoxal (MG) is one of the main precursors for AGE formation. Humans developed effective mechanism of the MG...

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Source

Identifiers

PMID: 24671236
DOI: 10.1007/s00787-014-0537-8

Genes

GLO1
HAGH

Variants

Provenance

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