The GLO1 C332 (Ala111) allele confers autism vulnerability: family-based genetic association and functional correlates.

doi:10.1016/j.jpsychires.2014.07.021

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Article

The GLO1 C332 (Ala111) allele confers autism vulnerability: family-based genetic association and functional correlates.

Journal of psychiatric research - 1 Dec 2014

Gabriele Stefano, Lombardi Federica, Sacco Roberto, Napolioni Valerio, Altieri Laura, Tirindelli Maria Cristina, Gregorj Chiara, Bravaccio Carmela, Rousseau Francis, Persico Antonio M

Abstract excerpt

Glyoxalase I (GLO1) is a homodimeric Zn(2+)-dependent isomerase involved in the detoxification of methylglyoxal and in limiting the formation of advanced glycation end-products (AGE). We previously found the rs4746 A332 (Glu111) allele of the GLO1 gene, which encodes for glyoxalase I, associated with "unaffected sibling" status in families with one or more children affected by Autism Spectrum Disorder (ASD). To...

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PMID: 25201284
DOI: 10.1016/j.jpsychires.2014.07.021

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GLO1

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