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Article

Addressing population-specific multiple testing burdens in genetic association studies.

Annals of human genetics - 1 Mar 2015

Sobota Rafal S, Shriner Daniel, Kodaman Nuri, Goodloe Robert, Zheng Wei, Gao Yu-Tang, Edwards Todd L, Amos Christopher I, Williams Scott M

Abstract excerpt

The number of effectively independent tests performed in genome-wide association studies (GWAS) varies by population, making a universal P-value threshold inappropriate. We estimated the number of independent SNPs in Phase 3 HapMap samples by: (1) the LD-pruning function in PLINK, and (2) an autocorrelation-based approach. Autocorrelation was also used to estimate the number of independent SNPs in whole genome...

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Identifiers

PMID: 25644736
DOI: 10.1111/ahg.12095
PMCID: PMC4334751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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