Article
Sifting the wheat from the chaff: prioritizing GWAS results by identifying consistency across analytical methods.
Genetic epidemiology - 1 Dec 2011
Oldmeadow Christopher, Riveros Carlos, Holliday Elizabeth G, Scott Rodney, Moscato Pablo, Wang Jie Jin, Mitchell Paul, Buitendijk Gabrielle H S, Vingerling Johannes R, Klaver Caroline C W, Klein Ronald, Attia John
Abstract excerpt
The curse of multiple testing has led to the adoption of a stringent Bonferroni threshold for declaring genome-wide statistical significance for any one SNP as standard practice. Although justified in avoiding false positives, this conservative approach has the potential to miss true associations as most studies are drastically underpowered. As an alternative to increasing sample size, we compare results from a...
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