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Article

The KrasG12D;Trp53fl/fl murine model of undifferentiated pleomorphic sarcoma is macrophage dense, lymphocyte poor, and resistant to immune checkpoint blockade.

PloS one - 1 Jan 2021

Hildebrand Karys M, Singla Arvind K, McNeil Reid, Marritt Kayla L, Hildebrand Kurt N, Zemp Franz, Rajwani Jahanara, Itani Doha, Bose Pinaki, Mahoney Douglas J, Jirik Frank R, Monument Michael J

Abstract excerpt

Sarcomas are rare, difficult to treat, mesenchymal lineage tumours that affect children and adults. Immunologically-based therapies have improved outcomes for numerous adult cancers, however, these therapeutic strategies have been minimally effective in sarcoma so far. Clinically relevant, immunologically-competent, and transplantable pre-clinical sarcoma models are essential to advance sarcoma immunology...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34242269
DOI: 10.1371/journal.pone.0253864
PMCID: PMC8270133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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