Article
Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American population.
BMC cancer - 31 Jan 2015
Leyton Yessica, Gonzalez-Hormazabal Patricio, Blanco Rafael, Bravo Teresa, Fernandez-Ramires Ricardo, Morales Sebastian, Landeros Natalia, Reyes Jose M, Peralta Octavio, Tapia Julio C, Gomez Fernando, Waugh Enrique, Ibañez Gladys, Pakomio Janara, Grau Gilberto, Jara Lilian
Abstract excerpt
BACKGROUND: Germline mutations in PALB2 have been identified in approximately 1% of familial breast cancer (BC) in several populations. Nevertheless its contribution in the South-American population is unknown. The goal of this study was to determine the prevalence of PALB2 mutations in the Chilean population. METHODS: 100 Chilean BRCA1/2-negatives familial BC cases were included for the PALB2 mutation analysis....
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