The associations between 6-n-propylthiouracil (PROP) intensity and taste intensities differ by TAS2R38 haplotype.

doi:10.1159/000371552

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Article

The associations between 6-n-propylthiouracil (PROP) intensity and taste intensities differ by TAS2R38 haplotype.

Journal of nutrigenetics and nutrigenomics - 1 Jan 2014

Fischer Mary E, Cruickshanks Karen J, Pankow James S, Pankratz Nathan, Schubert Carla R, Huang Guan-Hua, Klein Barbara E K, Klein Ronald, Pinto Alex

Abstract excerpt

BACKGROUND/AIMS: The influence of TAS2R38 haplotype on the relationship between the perceived intensity of propylthiouracil (PROP) and the basic tastes of salt, sweet, sour, and bitter (quinine) was evaluated in the Beaver Dam Offspring Study. METHODS: Genotyping was performed on 1,670 participants aged ≥45 years (mean age = 54.4; range = 45-84), and suprathreshold taste intensity was measured using filter paper...

Topics

Adult
Aged
Aged, 80 and over
Dose-Response Relationship, Drug
Female
Genetic Association Studies
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Propylthiouracil

Receptors, G-Protein-Coupled

Taste

Taste Perception

Young Adult

Taste Receptors, Type 2

Source

Open in PubMed Open full text

Identifiers

PMID: 25634331
DOI: 10.1159/000371552
PMCID: PMC4322864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25634331-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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