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Article

Recognition mechanism between Lac repressor and DNA with correlation network analysis.

The journal of physical chemistry. B - 19 Feb 2015

Xu Lishi, Ye Wei, Jiang Cheng, Yang Jingxu, Zhang Jinmai, Feng Yan, Luo Ray, Chen Hai-Feng

Abstract excerpt

Lac repressor is a DNA-binding protein which inhibits the expression of a series of genes involved in lactose metabolism. Lac repressor can bind at a random DNA site via nonspecific interactions; then, it rapidly translocates through the double chain of DNA until it finds the specific binding site. Therefore, the site transform between these two modes is essential for the specific recognition between Lac...

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Identifiers

PMID: 25633018
DOI: 10.1021/jp510940w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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