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Article

The endocytosis and signaling of the γδ T cell coreceptor WC1 are regulated by a dileucine motif.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2015

Hsu Haoting, Baldwin Cynthia L, Telfer Janice C

Abstract excerpt

WC1 proteins, which are specifically expressed by bovine γδ T cells from a gene array containing 13 members, are part of the scavenger receptor cysteine-rich family. WC1 cytoplasmic domains contains multiple tyrosines, one of which is required to be phosphorylated for TCR coreceptor activity, and a dileucine endocytosis motif. Like the TCR coreceptor CD4, WC1 is endocytosed in response to PMA. Because WC1...

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PMID: 25632004
DOI: 10.4049/jimmunol.1402020

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