Article
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2011
Baker Kristi, Qiao Shuo-Wang, Kuo Timothy T, Aveson Victoria G, Platzer Barbara, Andersen Jan-Terje, Sandlie Inger, Chen Zhangguo, de Haar Colin, Lencer Wayne I, Fiebiger Edda, Blumberg Richard S
Abstract excerpt
Cross-presentation of IgG-containing immune complexes (ICs) is an important means by which dendritic cells (DCs) activate CD8(+) T cells, yet it proceeds by an incompletely understood mechanism. We show that monocyte-derived CD8(-)CD11b(+) DCs require the neonatal Fc receptor for IgG (FcRn) to conduct cross-presentation of IgG ICs. Consequently, in the absence of FcRn, Fcγ receptor (FcγR)-mediated antigen uptake...
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