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Article

WC1 is a hybrid γδ TCR coreceptor and pattern recognition receptor for pathogenic bacteria.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2015

Hsu Haoting, Chen Chuang, Nenninger Ariel, Holz Lauren, Baldwin Cynthia L, Telfer Janice C

Abstract excerpt

WC1 proteins are uniquely expressed on γδ T cells and belong to the scavenger receptor cysteine-rich (SRCR) superfamily. While present in variable, and sometimes high, numbers in the genomes of mammals and birds, in cattle there are 13 distinct genes (WC1-1 to WC1-13). All bovine WC1 proteins can serve as coreceptors for the TCR in a tyrosine phosphorylation dependent manner, and some are required for the γδ T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25632007
DOI: 10.4049/jimmunol.1402021

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