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Transcriptional and Epigenetic Modulation of Human Rhinovirus–Induced CXCL10 Production by Cigarette Smoke

15 Oct 2013

Abstract excerpt

Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease. Cigarette smoking is the primary risk factor for the development of chronic obstructive pulmonary disease, and 25% of individuals with asthma smoke. Smokers experience both longer and more severe colds. We previously showed that cigarette smoke extract (CSE) inhibited HRV-induced expression of a range of epithelial...

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PMID: 24127910
DOI: 10.1165/rcmb.2013-0129oc

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