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Article

Gene silencing of SOCS3 by siRNA intranasal delivery inhibits asthma phenotype in mice.

PloS one - 1 Jan 2014

Zafra Ma Paz, Mazzeo Carla, Gámez Cristina, Rodriguez Marco Ainara, de Zulueta Ana, Sanz Veronica, Bilbao Izaskun, Ruiz-Cabello Jesús, Zubeldia Jose M, del Pozo Victoria

Abstract excerpt

Suppresors of cytokine signaling (SOCS) proteins regulate cytokine responses and control immune balance. Several studies have confirmed that SOCS3 is increased in asthmatic patients, and SOCS3 expression is correlated with disease severity. The objective of this study was to evaluate if delivering of SOCS3 short interfering RNA (siRNA) intranasally in lungs could be a good therapeutic approach in an asthma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24637581
DOI: 10.1371/journal.pone.0091996
PMCID: PMC3956882

Genes

SOCS3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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