Article

Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axis

2025-10-28

Abstract excerpt

Autophagy is an ancient catabolic process that has emerged as part of the innate immunity. Upon infection, autophagy is activated but key factors responsible remained unclear. Here, we show that interferon (IFN) released during viral infections subsequently activates autophagy via STAT1/5B-mediated upregulation of SOCS1. Our data shows that scavenging of IFNs diminishes autophagy induced by several respiratory vir...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3ca8a7e-1849-576c-ac51-2ef004ed5209
DOI: 10.1101/2025.10.28.685013

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axisDOI 10.1101/2025.10.28.685013Read

Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral ImmunitySemantic proximity Read

Autophagy-Virus Interplay: From Cell Biology to Human DiseaseSemantic proximity Read

Autophagy Regulates Interferon Signaling to Control SARS-CoV-2 InfectionSemantic proximity Read

Autophagy as a dual-faced host response to viral infectionsSemantic proximity Read

Type I interferons induce autophagy in certain human cancer cell linesSemantic proximity Read

Taming the Autophagy as a Strategy for Treating COVID-19Semantic proximity Read

A new mechanism of interferon’s antiviral action: Induction of autophagy, essential for paramyxovirus replication, is inhibited by the interferon stimulated gene, TDRD7Semantic proximity Read

Japanese Encephalitis Virus Activates Autophagy as a Viral Immune Evasion StrategySemantic proximity Read

Rift Valley Fever Virus Nucleoprotein Triggers Autophagy to Dampen Antiviral Innate Immune ResponsesSemantic proximity Read

Autophagy gene-dependent intracellular immunity triggered by interferon-γSemantic proximity Read

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilitiesSemantic proximity Read

SARS-CoV-2 promote autophagy to suppress type I interferon responseSemantic proximity Read