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Article

Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Mar 2013

Ebner Blake A, Ingram Melissa A, Barnes Justin A, Duvick Lisa A, Frisch Jill L, Clark H Brent, Zoghbi Huda Y, Ebner Timothy J, Orr Harry T

Abstract excerpt

Previous studies indicate that while transgenic mice with ATXN1[30Q]-D776-induced disease share pathological features caused by ATXN1[82Q] having an expanded polyglutamine tract, they fail to manifest the age-related progressive neurodegeneration seen in spinocerebellar ataxia type 1. The shared features include morphological alterations in climbing fiber (CF) innervation of Purkinje cells (PCs). To further...

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Identifiers

PMID: 23536093
DOI: 10.1523/JNEUROSCI.6311-11.2013
PMCID: PMC3633086

Genes

ATXN1
PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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