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Article

Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes.

Scientific reports - 22 Aug 2017

Öztürk Ece, Hobiger Stefanie, Despot-Slade Evelin, Pichler Michael, Zenobi-Wong Marcy

Abstract excerpt

Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes. Our data demonstrates that hypoxia controls the expression of RhoA in chondrocytes in a context-dependent manner on the culturing conditions. Within a 3D microenvironment, hypoxia suppresses...

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Identifiers

PMID: 28831110
DOI: 10.1038/s41598-017-09505-6
PMCID: PMC5567364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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