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Article

Lupus risk variants in the PXK locus alter B-cell receptor internalization

8 Jan 2015

Abstract excerpt

Genome wide association studies have identified variants in PXK that confer risk for humoral autoimmune diseases, including systemic lupus erythematosus (SLE or lupus), rheumatoid arthritis and more recently systemic sclerosis. While PXK is involved in trafficking of epidermal growth factor Receptor (EGFR) in COS-7 cells, mechanisms linking PXK to lupus pathophysiology have remained undefined. In an effort to...

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PMID: 25620976
DOI: 10.3389/fgene.2014.00450

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