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The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity

1 Jan 2018

Abstract excerpt

Replicative senescence and potential malignant transformation are great limitations in the clinical application of bone marrow-derived mesenchymal stem / stromal cells (MSCs). An abnormal DNA damage response may result in genomic instability, which is an integral component of aging and tumorigenesis. However, the effect of aging on the DNA damage response in MSCs is currently unknown. In the present study, we...

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PMID: 30008586
DOI: 10.7150/ijms.24635

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