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Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromes

30 May 2014

Abstract excerpt

The contribution of bone marrow mesenchymal stromal cells (BMMSCs) to the pathogenesis of myelodysplastic syndrome (MDS) has created controversies. In this study, we confirmed that BMMSCs from MDS patients showed prominent features of senescence, which were characterized by increased cell size, decreased proliferation and colony-forming potential, alteration of cytoskeleton, and increased senescence-associated...

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PMID: 24889123
DOI: 10.1111/ejh.12385

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