Article
Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells.
Stem cell reports - 10 Feb 2015
Huh Sung Jin, Clement Kendell, Jee David, Merlini Alessandra, Choudhury Sibgat, Maruyama Reo, Yoo Ronnie, Chytil Anna, Boyle Patrick, Ran Fei Ann, Moses Harold L, Barcellos-Hoff Mary Helen, Jackson-Grusby Laurie, Meissner Alexander, Polyak Kornelia
Abstract excerpt
Postnatal mammary gland development and differentiation occur during puberty and pregnancy. To explore the role of DNA methylation in these processes, we determined the genome-wide DNA methylation and gene expression profiles of CD24(+)CD61(+)CD29(hi), CD24(+)CD61(+)CD29(lo), and CD24(+)CD61(-)CD29(lo) cell populations that were previously associated with distinct biological properties at different ages and...
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