Article
Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics.
Cell stem cell - 3 Jul 2013
Choudhury Sibgat, Almendro Vanessa, Merino Vanessa F, Wu Zhenhua, Maruyama Reo, Su Ying, Martins Filipe C, Fackler Mary Jo, Bessarabova Marina, Kowalczyk Adam, Conway Thomas, Beresford-Smith Bryan, Macintyre Geoff, Cheng Yu-Kang, Lopez-Bujanda Zoila, Kaspi Antony, Hu Rong, Robens Judith, Nikolskaya Tatiana, Haakensen Vilde D, Schnitt Stuart J, Argani Pedram, Ethington Gabrielle, Panos Laura, Grant Michael, Clark Jason, Herlihy William, Lin S Joyce, Chew Grace, Thompson Erik W, Greene-Colozzi April, Richardson Andrea L, Rosson Gedge D, Pike Malcolm, Garber Judy E, Nikolsky Yuri, Blum Joanne L, Au Alfred, Hwang E Shelley, Tamimi Rulla M, Michor Franziska, Haviv Izhak, Liu X Shirley, Sukumar Saraswati, Polyak Kornelia
Abstract excerpt
Early full-term pregnancy is one of the most effective natural protections against breast cancer. To investigate this effect, we have characterized the global gene expression and epigenetic profiles of multiple cell types from normal breast tissue of nulliparous and parous women and carriers of BRCA1 or BRCA2 mutations. We found significant differences in CD44(+) progenitor cells, where the levels of many stem...
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