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Article

Loss of Endometrial Plasticity in Recurrent Pregnancy Loss

29 Sept 2015

Abstract excerpt

Menstruation drives cyclic activation of endometrial progenitor cells, tissue regeneration, and maturation of stromal cells, which differentiate into specialized decidual cells prior to and during pregnancy. Aberrant responsiveness of human endometrial stromal cells (HESCs) to deciduogenic cues is strongly associated with recurrent pregnancy loss (RPL), suggesting a defect in cellular maturation. MeDIP-seq...

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PMID: 26418742
DOI: 10.1002/stem.2222

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