Article

Genome-wide analysis highlights causal epigenetic link to age at menarche

2025-08-12

Abstract excerpt

Age at menarche, a key milestone in female reproductive development, has declined globally and is associated with cancer and other health outcomes. We investigated epigenetic mechanisms underlying pubertal timing by analysing genome-wide DNA methylation in blood from 3,429 women (mean age 56 years) using the Illumina HumanMethylation450 BeadChip. In the discovery cohort, comprising 479 participants from the Austra...

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Literature Corpus work: da1ea5e8-c364-5d58-a6e0-0831eed000ed
DOI: 10.1101/2025.08.10.25333251

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