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Article

Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision.

Progress in neuro-psychopharmacology & biological psychiatry - 3 Jun 2015

Bentea Eduard, Demuyser Thomas, Van Liefferinge Joeri, Albertini Giulia, Deneyer Lauren, Nys Julie, Merckx Ellen, Michotte Yvette, Sato Hideyo, Arckens Lutgarde, Massie Ann, Smolders Ilse

Abstract excerpt

There is considerable preclinical and clinical evidence indicating that abnormal changes in glutamatergic signaling underlie the development of mood disorders. Astrocytic glutamate dysfunction, in particular, has been recently linked with the pathogenesis and treatment of mood disorders, includin...

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Identifiers

PMID: 25619129
DOI: 10.1016/j.pnpbp.2015.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25619129-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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