Article
Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype.
Pharmacogenomics - 1 May 2010
Blum Shany, Vardi Moshe, Brown Jonathan B, Russell Allen, Milman Uzi, Shapira Chen, Levy Nina S, Miller-Lotan Rachel, Asleh Rabea, Levy Andrew P
Abstract excerpt
AIMS: Individuals with both diabetes mellitus (DM) and the Haptoglobin (Hp) 2-2 genotype are at increased risk of cardiovascular disease. As the antioxidant function of the Hp 2-2 protein is impaired, we sought to test the pharmacogenomic hypothesis that antioxidant vitamin E supplementation would provide cardiovascular protection to Hp 2-2 DM individuals. MATERIALS & METHODS: We determined the Hp genotype on DM...
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