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Article

Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2013

Al-Shami Amin, Crisostomo Jeannette, Wilkins Carrie, Xu Nianhua, Humphries Juliane, Chang Wei C, Anderson Stephen J, Oravecz Tamas

Abstract excerpt

The phenylalanyl-glycyl-glycyl-alanyl-prolyl (FG-GAP) domain plays an important role in protein-protein interactions, including interaction of integrins with their ligands. Integrin-α FG-GAP repeat-containing protein 2 (Itfg2) is a highly conserved protein in vertebrates that carries two FG-GAP domains, but its role in mammalian physiology is unknown. In this article, we show that Itfg2 is an intracellular...

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PMID: 23997217
DOI: 10.4049/jimmunol.1203534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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