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Article

From selection signatures in cattle to functional validation in mice: HSPA12B negatively regulates adipose browning and thermogenesis.

Journal of animal science - 8 Jan 2026

Gao Yaping, Wang Jinpeng, Jiang Qiang, Wang Xiuge, Ju Zhihua, Yang Chunhong, Wei Xiaochao, Zhang Yaran, Xiao Yao, Huang Jinming

Abstract excerpt

Local cattle breeds have been domesticated and adapted to various climatic environments through natural and artificial selection. However, the molecular mechanisms underlying cold adaptation remain unknown. Adipose tissue browning may play a crucial role in this adaptation. Our analysis of 777K SNP genotyping data from 25 local Chinese cattle breeds revealed that the HSPA12B (heat shock protein A12B) gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41615431
DOI: 10.1093/jas/skag016
PMCID: PMC12984435

Genes

HSPA12B
ELOVL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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