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Article

Species-specific influence of lithium on the activity of SLC13A5 (NaCT): lithium-induced activation is specific for the transporter in primates.

The Journal of pharmacology and experimental therapeutics - 1 Apr 2015

Gopal Elangovan, Babu Ellappan, Ramachandran Sabarish, Bhutia Yangzom D, Prasad Puttur D, Ganapathy Vadivel

Abstract excerpt

NaCT (SLC13A5) is a Na(+)-coupled transporter for Krebs cycle intermediates and is expressed predominantly in the liver. Human NaCT is relatively specific for citrate compared with other Krebs cycle intermediates. The transport activity of human NaCT is stimulated by Li(+), whereas that of rat NaCT is inhibited by Li(+). We studied the influence of Li(+) on NaCTs cloned from eight different species. Li(+)...

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PMID: 25617245
DOI: 10.1124/jpet.114.221523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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