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Article

Structure and inhibition mechanism of the human citrate transporter NaCT.

Nature - 1 Mar 2021

Sauer David B, Song Jinmei, Wang Bing, Hilton Jacob K, Karpowich Nathan K, Mindell Joseph A, Rice William J, Wang Da-Neng

Abstract excerpt

Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition to this essential role in energy metabolism, the tricarboxylate anion also acts as both a precursor and a regulator of fatty acid synthesis1-3. Thus, the rate of fatty acid synthesis correlates directly with the cytosolic concentration of citrate4,5. Liver cells import citrate through the sodium-dependent citrate...

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Source

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Identifiers

PMID: 33597751
DOI: 10.1038/s41586-021-03230-x
PMCID: PMC7933130

Genes

SLC13A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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