Article

Targeting an allosteric binding site in the citrate transporter NaCT (SLC13A5)

2026-06-08

Abstract excerpt

<h4>ABSTRACT</h4> The Na + -dependent citrate transporter NaCT (SLC13A5) is a key regulator of citrate homeostasis and has emerged as a therapeutic target for metabolic and neurological disease, including the SLC13A5 Epilepsy, a rare disease marked by severe sezures and neurodevelopmental delays. Current NaCT inhibitors are substrate-like molecules that competitively bind the substrate binding site. In this stud...

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Literature Corpus work: 1f742966-a395-58df-b78d-e5e051aa0477
DOI: 10.64898/2026.06.04.730233

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