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Article

Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.

Annals of neurology - 1 Jan 2013

Buck Dorothea, Albrecht Eva, Aslam Muhammad, Goris An, Hauenstein Natalie, Jochim Angela, Cepok Sabine, Grummel Verena, Dubois Bénédicte, Berthele Achim, Lichtner Peter, Gieger Christian, Winkelmann Juliane, Hemmer Bernhard

Abstract excerpt

OBJECTIVE: Intrathecal synthesis of immunoglobulin gamma (IgG) synthesis is frequently observed in patients with multiple sclerosis (MS). Whereas the extent of intrathecal IgG synthesis varies largely between patients, it remains rather constant in the individual patient over time. The aim of this study was to identify common genetic variants associated with the IgG index as a marker of intrathecal IgG synthesis...

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Source

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Identifiers

PMID: 23225573
DOI: 10.1002/ana.23749
PMCID: PMC3661208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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