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Article

Genetic Determinants of Antibody Levels in Cerebrospinal Fluid in Multiple Sclerosis: Possible Links to Endogenous Retroviruses.

International journal of molecular sciences - 9 Mar 2018

Emmer Alexander, Brütting Christine, Kornhuber Malte, Staege Martin S

Abstract excerpt

The pathogenesis of multiple sclerosis (MS) has not been clarified. In addition to environmental factors; genetic determinants have been implicated in the pathogenesis of MS. Furthermore, endogenous retroviruses (ERV) might play a role in MS. The presence of oligoclonal immunoglobulin in cerebrospinal fluid (CSF) is a typical feature of MS. Recently, genetic polymorphisms in loci on human chromosomes 6, 14 and 18...

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Identifiers

PMID: 29522453
DOI: 10.3390/ijms19030786
PMCID: PMC5877647

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