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Different expression of TSH receptor and NIS genes in thyroid cancer: role of epigenetics

18 Dec 2013

Abstract excerpt

The TSH receptor (TSHR) and sodium/iodide symporter (NIS) are key players in radioiodine-based treatment of differentiated thyroid cancers. While NIS (SLC5AS) expression is diminished/lost in most thyroid tumors, TSHR is usually preserved. To examine the mechanisms that regulate the expression of NIS and TSHR genes in thyroid tumor cells, we analyzed their expression after inhibition of ras-BRAF-MAPK and...

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PMID: 24353283
DOI: 10.1530/jme-13-0160

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